telaprevir experience from turkey
نویسندگان
چکیده
background in patients with chronic hepatitis c, triple drug regimens containing a protease inhibitor, peginterferon and ribavirin were found to significantly increase sustained virologic response rates compared to dual drug regimen containing pegylated interferon and ribavirin, especially in genotype 1. objectives in turkey, telaprevir has been used since march 2013. we aimed to evaluate results of patients with chronic hepatitis c treated with telaprevir, peginterferon and ribavirin. patients and methods we evaluated 28 patients with genotype 1 chronic hepatitis c infection treated with triple drug regimen containing telaprevir, in three medical centers in turkey, retrospectively. demographic data of patients, treatment indications, adverse events and outcomes were recorded. results of 28 patients intended to treat, 25 (89.2%) patients completed the treatment. overall, 21 (82.1%) patients had relapse and five patients were non-responder. regarding the treatment outcomes of telaprevir based regimen, 20/26 patients achieved sustained virological response. pruritus, rash, dysgeusia, anorectal discomfort and anemia were main adverse effects. blood transfusion and ribavirin dose reduction required for 7 and 11 patients, respectively. due to several adverse effects, 10 patients were hospitalized. conclusions although more frequent and severe adverse effects, telaprevir has been promising for patients with treatment-experienced hepatitis c.
منابع مشابه
Telaprevir Experience From Turkey
BACKGROUND In patients with chronic hepatitis C, triple drug regimens containing a protease inhibitor, peginterferon and ribavirin were found to significantly increase sustained virologic response rates compared to dual drug regimen containing pegylated interferon and ribavirin, especially in genotype 1. OBJECTIVES In Turkey, telaprevir has been used since March 2013. We aimed to evaluate res...
متن کاملComment to “Telaprevir Experience From Turkey”
We have read with great interest the article entitled " Telaprevir experience from Turkey " by Komur et al. recently (1). First of all, we have applauded the efforts of the authors and the editors of journal for putting forward this controversial and wondered topic for us. Currently, the hepatitis C treatment is in a very dynamic situation, due to newly introduced potent drugs. Therefore, the m...
متن کاملTuberculosis verrucosa cutis. Experience from eastern Turkey.
T verrucosa cutis (TBVC) is a paucibacillary form of cutaneous tuberculosis caused by exogenous reinfection in previously sensitized individuals. Inoculation occurs at sites of minor wounds or abrasions, and rarely from the patient’s own sputum. The TBVC usually occurs on the hands in adults, and on the lower extremities in children. In western countries, TBVC is a rare form of cutaneous tuberc...
متن کاملTelaprevir
Telaprevir (LY 570310; LY-570310; LY570310; MP 424; MP-424; VX 950; VX-950) is an orally administered peptidomimetic inhibitor of the hepatitis C virus (HCV) protease NS3/4A. It is being developed by Vertex Pharmaceuticals and its licensees for the treatment of HCV infections and has recently been submitted to the US FDA for approval. As the first ever HCV protease inhibitor in phase III develo...
متن کاملGnathic osteosarcomas, experience of four institutions from Turkey.
Osteosarcoma is the most frequent primary gnathic sarcoma. Neither the etiology nor the variables effecting the prognosis are fully known due mostly to the rarity of gnathic osteosarcomas. To date a considerable number of clinicopathologic features have been suggested in the evaluation of gnathic osteosarcomas. Still there is a need to experience on several aspects of management. The aim of thi...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
hepatitis monthlyجلد ۱۵، شماره ۲، صفحات ۰-۰
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023