telaprevir experience from turkey

نویسندگان

suheyla komur department of infectious diseases, cukurova university, adana, turkey; department of infectious diseases, cukurova university, adana, turkey. tel: +90-5052677498, fax: +90-3223387164

behice kurtaran department of infectious diseases, cukurova university, adana, turkey

ayse seza inal department of infectious diseases, cukurova university, adana, turkey

husnu pullukcu department of infectious diseases, ege university, izmir, turkey

چکیده

background in patients with chronic hepatitis c, triple drug regimens containing a protease inhibitor, peginterferon and ribavirin were found to significantly increase sustained virologic response rates compared to dual drug regimen containing pegylated interferon and ribavirin, especially in genotype 1. objectives in turkey, telaprevir has been used since march 2013. we aimed to evaluate results of patients with chronic hepatitis c treated with telaprevir, peginterferon and ribavirin. patients and methods we evaluated 28 patients with genotype 1 chronic hepatitis c infection treated with triple drug regimen containing telaprevir, in three medical centers in turkey, retrospectively. demographic data of patients, treatment indications, adverse events and outcomes were recorded. results of 28 patients intended to treat, 25 (89.2%) patients completed the treatment. overall, 21 (82.1%) patients had relapse and five patients were non-responder. regarding the treatment outcomes of telaprevir based regimen, 20/26 patients achieved sustained virological response. pruritus, rash, dysgeusia, anorectal discomfort and anemia were main adverse effects. blood transfusion and ribavirin dose reduction required for 7 and 11 patients, respectively. due to several adverse effects, 10 patients were hospitalized. conclusions although more frequent and severe adverse effects, telaprevir has been promising for patients with treatment-experienced hepatitis c.

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Telaprevir Experience From Turkey

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Comment to “Telaprevir Experience From Turkey”

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عنوان ژورنال:
hepatitis monthly

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